Measure Crossover Interference

This webpage calculates quantities related to crossover interference for a single type of chromosomes from multiple samples of measured crossover positions. The tool was introduces in Ernst et al., Nat. Commun. (2024). Positions need to be specified in fractions of the total chromosome length, so they are numbers between 0 and 1. The chromosome length can be specified in units of micrometer (µm) for cytological data, units of megabases (Mb) for genetic data, or left set to 1 to obtain results normalized to the chromosome length.

Input

• Chromosome length:
• Is genetic data (Measurements will be corrected for 50% random sub-sampling)
• Observed normalized crossover positions (comma-separated positions; one line per sample):
  
  Load example data (A. thalania, wild-type, male, chromosome 1) from Durand et al., Nat. Commun. (2022) and Singh et al., PNAS (2023)
  Randomize input by shuffling crossover positions
• Bin count for calculating Coefficient of Coincidence

Output

• Several quantities below will be reported as mean ± standard error, where the standard error is determined using bootstrapping 1000 times. Consequently, the standard error will change slightly with each calculation.
• Interference length:
• Additional data:
• Coefficient of Coincidence (CoC):